Journal: Frontiers in cellular neuroscience

Article Title: Alterations of Electrophysiological Properties and Ion Channel Expression in Prefrontal Cortex of a Mouse Model of Schizophrenia.

doi: 10.3389/fncel.2019.00554

Figure Lengend Snippet: FIGURE 1 | MIA-SI animals develop schizophrenia-like behaviors, including deficits in jumping behavior, social novelty preference, working memory and sensorimotor gating function. (A) Overview of the experimental design. OFT, open field test; SIT, social interaction test; RAM, radial arm maze; PPI, prepulse inhibition. (B) Total distance traveled was not changed by MIA-SI in OFT. (C) Increased jumping time was observed in MIA-SI animals in OFT. (D) Top, time spent in the non-social chamber (inanimate) versus the social chamber (stranger 1) during the sociability session in SIT, indicating MIA-SI didn’t affect sociability. Bottom, time spent in the chamber with familiar mouse (stranger 1) versus that with novel mouse (stranger 2) during social novelty preference session in SIT, suggesting MIA-SI caused deficit in social novelty preference. (E) Working memory errors committed across five test days in RAM test. (F) Average daily working memory errors over five test days was increased in MIA-SI animals. (G) Time to complete the trial across five test days in RAM test. (H) PPI deficits following poly I:C challenge and isolation rearing. ∗p < 0.05; ∗∗∗p < 0.001. Control, n = 7; MIA-SI, n = 8.

Article Snippet: Prepulse Inhibition Prepulse inhibition (PPI) was measured using an acoustic startle reflex system (Med Associates Inc., United States) as described previously (Hadar et al., 2018).

Techniques: Inhibition, Isolation, Control

Journal: Neuropsychopharmacology

Article Title: Modern Clinical Research on LSD

doi: 10.1038/npp.2017.86

Figure Lengend Snippet: Modern Clinical Placebo-Controlled LSD Studies

Article Snippet: Schmid et al , 2015 , Acoustic startle , Disruption of prepulse inhibition (PPI).

Techniques: Clinical Proteomics, Disruption, Inhibition, Drug discovery, Concentration Assay, Activation Assay, Functional Assay, Activity Assay